This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.
Also known as: lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6; AI196731
FAS belongs to the death receptor subfamily of the TNF receptor superfamily.
It has been shown to play a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.
The interaction of FAS with its ligand allows the formation of a deathinducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10.
The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade and leads to apoptosis.
The Fas/TNFRSF6/CD95 insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided
For reasearch use only. Not for use in humans.
Caractéristiques techniques
Marque
R&D Systems
Réf. B-LABO
BL-RE-109005
Réf. fabricant
18704799
Expression
<i>m</i>Fas
Numéro d’adhésion
NP_032013
Concentration
10 μg at 0.2 μg/μL
Formule
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Type d’insert
997 bp
Identification génétique (Entrez)
355
Contenu et stockage
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Espèces
Mouse
Quantité
10 μg
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