Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124417 |
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| Réf. fabricant | 18716566 |
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| Nom chimique ou matériau | N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide |
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| CAS | 1049722-30-6 |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>32</sub>H<sub>36</sub>N<sub>10</sub>O<sub>2</sub> |
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| Pureté | 98% |
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