Caged ABT 594 (Cat. No. 6576); suitable for one- or two-photon photolysis
DPNB-ABT 594 is a nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ∽2 ms.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124420 |
| Réf. fabricant | 18728246 |
| Nom chimique ou matériau | 5-(((2 R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine |
| Quantité | 5 mg |
| Cible | Nicotinic (a4b2) Receptor Agonists |
| Formule moléculaire | C<sub>31</sub>H<sub>46</sub>ClN<sub>3</sub>O<sub>11</sub> |
| Poids de la formule | 672.16 |
| Pureté | 98% |
