GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes
in vitro
. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-124488 |
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| Réf. fabricant | 18722449 |
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| Nom chimique ou matériau | 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine |
|---|
| CAS | 870483-87-7 |
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| Quantité | 50 mg |
|---|
| Cible | Additional RTK Inhibitors |
|---|
| Formule moléculaire | C<sub>20</sub>H<sub>22</sub>N<sub>4</sub>O<sub>3</sub> |
|---|
| Poids de la formule | 366.41 |
|---|
| Pureté | >99% |
|---|
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