STAT5-SUMO protein-protein interaction inhibitor
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir
in vitro
.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124515 |
| Réf. fabricant | 18738416 |
| Nom chimique ou matériau | 3-Hydroxy-1,2,3-benzotriazin-4(3 H)-one |
| CAS | 28230-32-2 |
| Quantité | 100 mg |
| Solubilité | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| Cible | Antiviral Compounds |
| Formule moléculaire | C<sub>7</sub>H<sub>5</sub>N<sub>3</sub>O<sub>2</sub> |
| Poids de la formule | 163.14 |
| Type de produit | Inhibitor |
| Pureté | 98% |
