HSF1 inhibitor
KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth
in vivo
.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124530 |
| Réf. fabricant | 18743978 |
| Nom chimique ou matériau | KRIBB11 |
| CAS | 342639-96-7 |
| Synonyme | N<sup>2</sup>-1H-Indazol-5-yl-N<sup>6</sup>-methyl-3-nitro-2,6-pyridinediamine |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Formule moléculaire | C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>2</sub>N<sub>6</sub>O<sub>2</sub> |
| Poids de la formule | 284.27 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >99% |
