Selective TRPV4 antagonist
RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124537 |
| Réf. fabricant | 18769516 |
| Nom chimique ou matériau | 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide |
| CAS | 946387-07-1 |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>14</sub>H<sub>22</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>S |
| Poids de la formule | Observed MW: 353.31 |
