Biotinylated ASGPR ligand for LYTAC research and development
Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary
N
-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124559 |
| Réf. fabricant | 18785496 |
| Quantité | 50 μg |
| Cible | Degrader Building Blocks |
| Formule moléculaire | C<sub>83</sub>H<sub>146</sub>N<sub>14</sub>O<sub>34</sub>S |
| Pureté | 0.9 |
