Selective USP25 and USP28 inhibitor
AZ1 USP25/28 inhibitor is a selective inhibitor of USP28 (IC50 = 0.6 μM, Kd= 0.2 - 3.7 μM) and USP25 (IC50 = 0.7 μM). AZ1 USP25/28 inhibitor exhibits selectivity for USP25 and USP28 over other DUB family members. The compound dose-dependently reduces c-Myc levels in colon carcinoma cells
in vitro
and induces cell death (EC50 values are 18 - 20 μM). In a mouse Alzheimer's disease model, AZ1 USP25/28 inhibitor reduces amyloid burden, attenuates microglial activation and improves synaptic and cognitive function.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124610 |
| Réf. fabricant | 18795735 |
| Nom chimique ou matériau | 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol |
| CAS | 2165322-94-9 |
| Quantité | 50 mg |
| Cible | USP28 |
| Formule moléculaire | C<sub>17</sub>H<sub>16</sub>BrF<sub>4</sub>NO<sub>2</sub> |
| Pureté | 0.98 |
