CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124621 |
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| Réf. fabricant | 18797199 |
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| Nom chimique ou matériau | (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone |
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| CAS | 1181081-71-9 |
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| Quantité | 50 mg |
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| Cible | KCC2 Activators |
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| Formule moléculaire | C<sub>14</sub>H<sub>14</sub>FN<sub>3</sub>O<sub>2</sub>S |
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| Poids de la formule | 307.34 |
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| Pureté | >98% |
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