Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124639 |
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| Réf. fabricant | 18756206 |
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| Nom chimique ou matériau | 8,8 '-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide] |
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| CAS | 2084868-04-0 |
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| Quantité | 10 mg |
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| Cible | Proteasome Inhibitors |
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| Formule moléculaire | C<sub>30</sub>H<sub>24</sub>N<sub>6</sub>O<sub>2</sub>S<sub>4</sub> |
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| Pureté | 0.98 |
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