YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-124647 |
|---|
| Réf. fabricant | 18789956 |
|---|
| Nom chimique ou matériau | 3-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4-methoxy-N,N-dimethyl-[1,1-biphenyl]-3-carboxamide dihydrochloride |
|---|
| CAS | 1804978-82-2 |
|---|
| Quantité | 10 mg |
|---|
| Cible | OX2 Receptor Agonists |
|---|
| Formule moléculaire | C<sub>33</sub>H<sub>37</sub>N<sub>5</sub>O<sub>5</sub>S0.2 HCl |
|---|
| Poids de la formule | 2778 |
|---|
| Pureté | 98% |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
