Potent VEGFR, PDGFR and FGFR inhibitor
Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124688 |
| Réf. fabricant | 18756736 |
| Nom chimique ou matériau | Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate |
| CAS | 656247-17-5 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>31</sub>H<sub>33</sub>N<sub>5</sub>O<sub>4</sub> |
| Pureté | 98% |
