PARP inhibitor; cytoprotectant
BGP 15 is a PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. Also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124695 |
| Réf. fabricant | 18719756 |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>14</sub>H<sub>22</sub>N<sub>4</sub>O<sub>2</sub>.2HCl |
| Poids de la formule | 351.27 |
| Type de produit | Inhibitor |
| Pureté | 98% |
