KV7.2/KV7.3 channel opener
ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124733 |
| Réf. fabricant | 18795356 |
| Nom chimique ou matériau | N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide |
| CAS | 582323-16-8 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>11</sub>H<sub>6</sub>ClF<sub>2</sub>N<sub>3</sub>O |
| Poids de la formule | Observed MW: 269.63 |
