Potent and selective TRPM8 antagonist
AMG 333 is a potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 >20 μM, TRPV1/V3/V4/A1). Inhibits icilin -induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124741 |
| Réf. fabricant | 18778166 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>20</sub>H<sub>12</sub>F<sub>5</sub>N<sub>3</sub>O<sub>4</sub> |
| Poids de la formule | 453.33 |
| Type de produit | Antagonist |
| Pureté | 98% |
