AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC50 values are 0.2 1.8, and 2.5 nM, respectively). It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR (>2,900-fold), CDK2 (>50,000-fold), and p38 (>50,000-fold).
In vitro
, it has antiproliferative effects on tumor cell lines with deregulated FGFR expression.
In vivo
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-124762 |
|---|
| Réf. fabricant | 18717376 |
|---|
| Nom chimique ou matériau | rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide |
|---|
| CAS | 1035270-39-3 |
|---|
| Quantité | 10 mg |
|---|
| Cible | FGF Receptor Inhibitors |
|---|
| Formule moléculaire | C<sub>26</sub>H<sub>33</sub>N<sub>5</sub>O<sub>3</sub> |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
