Fluorescent retinoic acid analog; solvochromatic probe
DC 271 is a fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII)). Solvochromatic probe: fluorescent λex, λem, and quantum yield affected by solvent type. Activates same genes as endogenous retinoic acid in human keratinocyte cells (HaCaT) when incubated for 72 h at 1 μM. Also elicits cellular responses consistent with those of retinoic acid. Excitation λ = 351, 350, 382 and 378 nm in DMSO, EtOH, DCM and Toluene, respectively; emission λ = 442, 461, 572 and 447 nm in DMSO, EtOH, DCM and Toluene, respectively. Quantum yield = 19.3, 1.14, 71.45, 80.21 % in DMSO, EtOH, DCM and Toluene, respectively
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124764 |
| Réf. fabricant | 18717356 |
| Nom chimique ou matériau | 4-[2-[1,2,3,4-Tetrahydro-4,4-dimethyl-1-(1-methylethyl)-6-quinolinyl]ethynyl]benzoic acid |
| CAS | 198696-03-6 |
| Quantité | 5 mg |
| Cible | Fluorescent Receptor Probes |
| Formule moléculaire | C<sub>23</sub>H<sub>25</sub>NO<sub>2</sub> |
| Pureté | 0.98 |
