Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability
in vitro
. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124766 |
| Réf. fabricant | 18719296 |
| CAS | 1210945-69-9 |
| Quantité | 10 mg |
| Solubilité | Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH |
| Formule moléculaire | C<sub>17</sub>H<sub>19</sub>N<sub>7</sub>O<sub>5</sub>S<sub>3</sub>.CF<sub>3</sub>CO<sub>2</sub>H |
| Poids de la formule | 611.59 |
| Type de produit | Antagonist |
| Pureté | 98% |
