Potent and selective p38α/β inhibitor
PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes
in vitro
. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.
PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124770 |
| Réf. fabricant | 18706776 |
| Nom chimique ou matériau | (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide |
| CAS | 1358027-80-1 |
| Quantité | 10 mg |
| Cible | p38 Inhibitors |
| Formule moléculaire | C<sub>22</sub>H<sub>19</sub>BrF<sub>2</sub>N<sub>2</sub>O<sub>3</sub> |
| Poids de la formule | 477.3 |
| Pureté | >98% |
