γ-secretase inhibitor; inhibits Notch pathway
DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without
KLF4
and
CMYC
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124783 |
| Réf. fabricant | 18724957 |
| Nom chimique ou matériau | DBZ |
| CAS | 209984-56-5 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 50 mg |
| Formule moléculaire | C26H23F2N3O3 |
| Poids de la formule | 463.48 |
