Selective GPR55 antagonist
CID 16020046 is a selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124835 |
| Réf. fabricant | 18776246 |
| Nom chimique ou matériau | 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid |
| CAS | 834903-43-4 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>19</sub>N<sub>3</sub>O<sub>4</sub> |
| Poids de la formule | Observed MW: 425.44 |
