OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons
in vitro
. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124884 |
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| Réf. fabricant | 18746306 |
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| Nom chimique ou matériau | Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate |
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| CAS | 300803-69-4 |
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| Quantité | 50 mg |
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| Formule moléculaire | C<sub>21</sub>H<sub>17</sub>N<sub>3</sub>O<sub>6</sub> |
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| Pureté | 98% |
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