High affinity KAT6A (MOZ) competitive inhibitor
WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells
in vitro
(IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124924 |
| Réf. fabricant | 18738686 |
| Nom chimique ou matériau | 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide |
| CAS | 2055397-28-7 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>18</sub>H<sub>13</sub>F<sub>2</sub>N<sub>3</sub>O<sub>3</sub>S |
| Poids de la formule | 389.38 |
| Pureté | 98% |
