High affinity and selective PLK4 inhibitor
High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.
Centrinone is a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels
in vitro
. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124929 |
| Réf. fabricant | 18758578 |
| Nom chimique ou matériau | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine |
| CAS | 1798871-30-3 |
| Quantité | 10 mg |
| Cible | Polo-like Kinase Inhibitors |
| Formule moléculaire | C<sub>26</sub>H<sub>25</sub>F<sub>2</sub>N<sub>7</sub>O<sub>6</sub>S<sub>2</sub> |
| Poids de la formule | 633.65 |
| Pureté | >98% |
