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Tocris Bioscience™ MRTX 849

Name: Tocris Bioscience™ MRTX 849
Brand: Tocris Bioscience
SKU: 18717386
Price: 311.01 EUR
Availability: InStock

Réf. : BL-RE-124971Réf. fabricant : 18717386 10 mg

311,01 € HT

Mutation-selective inhibitor of KRASG12C

Nom chimique ou matériau: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
CAS: 2326521-71-3
Quantité: 10 mg
Cible: Ras GTPase Inhibitors
Formule moléculaire: C₃₂H₃₅ClFN₇O₂
Marque: Tocris Bioscience

MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM). MRTX 849 covalently binds to KRASG12C at the cysteine at residue 12 and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state. MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types. It is orally bioavailable.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-124971
Réf. fabricant	18717386
Nom chimique ou matériau	4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2 S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2 S)-2-piperazineacetonitrile
CAS	2326521-71-3
Quantité	10 mg
Cible	Ras GTPase Inhibitors
Formule moléculaire	C<sub>32</sub>H<sub>35</sub>ClFN<sub>7</sub>O<sub>2</sub>
Pureté	98%

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Tocris Bioscience™ MRTX 849

Caractéristiques techniques

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