Selective 5-HT2A inverse agonist
Pimavanserin (also known as ACP-103) is a selective, potent 5-HT2A receptor inverse agonist (IC50 = 2 nM). Pimavanserin displays ∼ 40-fold higher affinity for 5-HT2A over 5-HT2C receptor. Chronic administration of Pimavanserin, suppresses amyloid-β production and improves anxiety-related behavior and memory in Alzheimer's disease mouse models. Pimavanserin shows protective effects on midbrain dopaminergic neurons in a rat model of Parkinson's Disease.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124974 |
| Réf. fabricant | 18729916 |
| Nom chimique ou matériau | N-[(4-Fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]urea |
| CAS | 706779-91-1 |
| Quantité | 50 mg |
| Cible | 5-HT2A Receptor Antagonists |
| Formule moléculaire | C<sub>25</sub>H<sub>34</sub>FN<sub>3</sub>O<sub>2</sub> |
| Pureté | 98% |
