Potent and selective N-SMase2 inhibitor; brain penetrant
DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and
in vivo
. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125060 |
| Réf. fabricant | 18767166 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>21</sub>H<sub>18</sub>N<sub>2</sub>O<sub>3</sub>S |
| Poids de la formule | 378.45 |
| Type de produit | Inhibitor |
| Pureté | 98% |
