G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines
in vitro
. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125088 |
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| Réf. fabricant | 30000024 |
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| Nom chimique ou matériau | 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile |
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| CAS | 2457232-14-1 |
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| Quantité | 10 mg |
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| Cible | Glucose 6 Phosphate Dehydrogenase |
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| Formule moléculaire | C<sub>14</sub>H<sub>12</sub>N<sub>4</sub>OS |
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| Pureté | 0.98 |
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