Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125098 |
| Réf. fabricant | 18715676 |
| Nom chimique ou matériau | 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside |
| CAS | 879004-92-9 |
| Quantité | 25 mg |
| Cible | ASGPR1 |
| Formule moléculaire | C<sub>16</sub>H<sub>30</sub>N<sub>4</sub>O<sub>9</sub> |
