Potent and selective p97 ATPase (VCP) allosteric inhibitor
NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells
in vitro
(IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125115 |
| Réf. fabricant | 18749126 |
| Nom chimique ou matériau | 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine |
| CAS | 1418013-75-8 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>27</sub>H<sub>28</sub>N<sub>4</sub>O<sub>3</sub>S<sub>2</sub> |
| Poids de la formule | Observed MW: 520.67 |
