"/> Tocris™ AGI 5198 | B-LABO France

Tocris™ AGI 5198

Réf. : BL-RE-125134Réf. fabricant : 18739466 5 mg
145,78 € HT

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)

Nom chimique ou matériau
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
CAS
1355326-35-0
Quantité
5 mg
Cible
Dehydrogenase Inhibitors
Formule moléculaire
C27H31FN4O2
Marque
Tocris

AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1,

in vitro

in vivo

. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-125134
Réf. fabricant18739466
Nom chimique ou matériauN-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
CAS1355326-35-0
Quantité5 mg
CibleDehydrogenase Inhibitors
Formule moléculaireC<sub>27</sub>H<sub>31</sub>FN<sub>4</sub>O<sub>2</sub>
Pureté0.98
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