ASIC blocker; antihyperalgesic
Diminazene aceturate is an ASIC blocker (IC50 values are 202, ∽320, ∽320 and 864 nM for ASIC1b, ASIC1a, ASIC3 and ASIC2a, respectively). Exhibits no activity in ENaC channels expressed in oocytes. Accelerates desensitization of ASIC currents in hippocampal neurons. Inhibits mesotrypsin (Ki = 3.6?0.3 μM). Displays
in vitro
and
in vivo
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125142 |
| Réf. fabricant | 18725816 |
| Nom chimique ou matériau | 4,4'-(1-Triazene-1,3-diyl)bis[benzenecarboximidamide] bis(<i>N</i>-acetylglycinate) |
| CAS | 908-54-3 |
| Quantité | 100 mg |
| Formule moléculaire | C<sub>14</sub>H<sub>15</sub>N<sub>7</sub>.2C<sub>4</sub>H<sub>7</sub>NO<sub>3</sub> |
| Poids de la formule | 515.52 |
| Type de produit | ASIC Blocker, Antihyperalgesic |
| Pureté | 98% |
