WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells
in vitro
. Cell permeant. Suitable for use
in vitro
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-125155 |
|---|
| Réf. fabricant | 18737146 |
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| Nom chimique ou matériau | N'-(4-Fluoro-5-methyl-[1,1 '-biphenyl]-3-carbonyl)benzenesulfonohydrazide |
|---|
| CAS | 2055397-18-5 |
|---|
| Quantité | 10 mg |
|---|
| Cible | Histone Acetyltransferase Inhibitors |
|---|
| Formule moléculaire | C<sub>20</sub>H<sub>17</sub>FN<sub>2</sub>O<sub>3</sub>S |
|---|
| Pureté | 0.98 |
|---|
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