Potent CD38 inhibitor; active in vivo
CD38 inhibitor 78c is a potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC50 values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD+ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD+ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125170 |
| Réf. fabricant | 18736396 |
| Nom chimique ou matériau | 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1 H)-quinolinone |
| CAS | 1700637-55-3 |
| Quantité | 5 mg |
| Cible | Hydrolase Inhibitors |
| Formule moléculaire | C<sub>22</sub>H<sub>27</sub>N<sub>3</sub>O<sub>3</sub>S |
| Pureté | 0.98 |
