Potent and selective PRMT 4 inhibitor
TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used
in vivo
. TP 064 inhibits the monocyte/macrophage-driven inflammation in
ex vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125189 |
| Réf. fabricant | 18727538 |
| Nom chimique ou matériau | TP 064 |
| Synonyme | N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in 1eq. HCl and to 100mM in DMSO |
| Formule moléculaire | C<sub>28</sub>H<sub>34</sub>N<sub>4</sub>O<sub>2</sub> |
| Poids de la formule | 458.6 |
| Forme physique | Solid |
| Couleur | White |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
