Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity
in vitro
by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125210 |
| Réf. fabricant | 18787166 |
| Nom chimique ou matériau | 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4 H-1-benzopyran-4-one |
| CAS | 4049-38-1 |
| Quantité | 5 mg |
| Cible | TRPV Inhibitors |
| Formule moléculaire | C<sub>15</sub>H<sub>12</sub>O<sub>6</sub> |
| Pureté | 0.98 |
