Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in reprogramming of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125241 |
| Réf. fabricant | 18776356 |
| Nom chimique ou matériau | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| CAS | 627518-40-5 |
| Quantité | 10 mg |
| Cible | PDGF Receptor Inhibitors |
| Formule moléculaire | C<sub>18</sub>H<sub>16</sub>FN<sub>3</sub>O<sub>2</sub> |
| Poids de la formule | 2273 |
| Pureté | 98% |
