Potent and selective GPR84 agonist
DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125244 |
| Réf. fabricant | 18727326 |
| Nom chimique ou matériau | 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide |
| Quantité | 10 mg |
| Cible | Free Fatty Acid Receptor Agonists |
| Formule moléculaire | C<sub>17</sub>H<sub>14</sub>ClNO<sub>2</sub> |
| Poids de la formule | 1263 |
| Pureté | 98% |
