"/> Tocris Bioscience™ ASP 3026 | B-LABO France

Tocris Bioscience™ ASP 3026

Name: Tocris Bioscience™ ASP 3026
Brand: Tocris Bioscience
SKU: 18730518
Price: 667.37 EUR
Availability: InStock

Réf. : BL-RE-125349Réf. fabricant : 18730518 50 mg

667,37 € HT

Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor

Nom chimique ou matériau: N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
CAS: 1097917-15-1
Quantité: 50 mg
Cible: ALK Inhibitors
Formule moléculaire: C₂₉H₄₀N₈O₃S
Marque: Tocris Bioscience

ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells

in vitro

. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-125349
Réf. fabricant	18730518
Nom chimique ou matériau	N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
CAS	1097917-15-1
Quantité	50 mg
Cible	ALK Inhibitors
Formule moléculaire	C<sub>29</sub>H<sub>40</sub>N<sub>8</sub>O<sub>3</sub>S
Poids de la formule	580.74
Pureté	>99%

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Tocris Bioscience™ ASP 3026

Caractéristiques techniques

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