Molecular glue; pre-mRNA splicing modulator
Indisulam is an acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39 (also designated CAPERα, HCC1, FSAP59, and RNPC2), via binding to DCAF15. Acts as a pre-mRNA splicing modulator (SPLAMs; splicing inhibitor sulfonamides), causes aberrant pre-mRNA splicing. Suppresses proliferation of cancer cell lines. Reduces viability of HCT-116 cells (IC50 = 0.56 μM). Induces cell cycle arrest in the G1 phase in cancer cell lines. Also a high affinity carbonic anhydrase isozyme XII (hCA XII) inhibitor (Ki = 3.0-5.7 nM).
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125352 |
| Réf. fabricant | 18705616 |
| Nom chimique ou matériau | N1-(3-Chloro-1 H-indol-7-yl)-1,4-benzenedisulfonamide |
| CAS | 165668-41-7 |
| Quantité | 5 mg |
| Cible | Ubiquitin Ligase (E3) Inhibitors |
| Formule moléculaire | C<sub>14</sub>H<sub>12</sub>ClN<sub>3</sub>O<sub>4</sub>S<sub>2</sub> |
| Poids de la formule | 385.84 |
| Type de produit | pre-mRNA Splicing Modulator |
| Pureté | 98% |
