Potent and selective Dyrk1B kinase inhibitor
AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular
in vitro
activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125354 |
| Réf. fabricant | 18730939 |
| Nom chimique ou matériau | 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine |
| CAS | 1679330-37-0 |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in 1eq. HCl and to 100mM in DMSO |
| Formule moléculaire | C<sub>19</sub>H<sub>16</sub>N<sub>4</sub> |
| Poids de la formule | 300.36 |
| Forme physique | Solid |
| Couleur | White |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
