Selective TRPC3 inhibitor
Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry
in vitro
), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125398 |
| Réf. fabricant | 18768946 |
| Nom chimique ou matériau | N-[4-[3,5-bis(Trifluoromethyl)-1 H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide |
| CAS | 1315323-00-2 |
| Quantité | 50 mg |
| Cible | TRPC Channel Blockers |
| Formule moléculaire | C<sub>18</sub>H<sub>13</sub>F<sub>6</sub>N<sub>3</sub>O<sub>2</sub>S |
| Pureté | 0.98 |
