Potent and reversible SARM1 NAD hydrolase inhibitor
DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters.
In vitro
, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125420 |
| Réf. fabricant | 18717336 |
| Nom chimique ou matériau | 5-Iodoisoquinoline |
| CAS | 58142-99-7 |
| Quantité | 50 mg |
| Cible | Hydrolase Inhibitors |
| Formule moléculaire | C<sub>9</sub>H<sub>6</sub>IN |
| Pureté | 0.98 |
