EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production
in vivo
. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons
in vitro
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125473 |
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| Réf. fabricant | 18758836 |
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| Nom chimique ou matériau | 1-Methyl-2,5-bis[[[(1 S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide |
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| CAS | 1206480-93-4 |
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| Quantité | 10 mg |
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| Cible | Cytokine Compounds |
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| Formule moléculaire | C<sub>44</sub>H<sub>60</sub>IN<sub>5</sub>O<sub>4</sub> |
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| Pureté | 98% |
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