FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3
Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active
in vivo
.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125496 |
| Réf. fabricant | 18768886 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>15</sub>H<sub>8</sub>O<sub>6</sub> |
| Poids de la formule | 284.22 |
| Type de produit | Inhibitor |
| Pureté | 98% |
