Neratinib is a potent, irreversible inhibitor of HER-2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50 = 59 nM and 92 nM, respectively). Neratinib reduces receptor autophosphorylation and proliferation of EGFR-dependent cancer cells, blocks cell-cycle progression and inhibits HER-2 signaling pathways. Neratinib suppresses proliferation of gefitinib -resistant non-small cell lung cancer cells expressing mutant EGFR. Also inhibits MST1 (IC50 = 37.7 nM). Orally bioavailable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125516 |
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| Réf. fabricant | 18768416 |
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| Nom chimique ou matériau | (2 E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
|---|
| CAS | 698387-09-6 |
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| Quantité | 10 mg |
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| Cible | EGF Receptor Inhibitors |
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| Formule moléculaire | C<sub>30</sub>H<sub>29</sub>ClN<sub>6</sub>O<sub>3</sub> |
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| Pureté | 0.98 |
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