"/> Tocris Bioscience™ WS 383 | B-LABO France

Tocris Bioscience™ WS 383

Réf. : BL-RE-125601Réf. fabricant : 18797056 50 mg
895,23 € HT

Potent, selective and reversible DCN1-UBC12 interaction inhibitor

Nom chimique ou matériau
5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
CAS
2247544-02-9
Quantité
50 mg
Cible
Ubiquitin Ligase (E3) Inhibitors
Formule moléculaire
C18H20ClN9S2.HCl
Marque
Tocris Bioscience

WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC50 = 11 nM). The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases. including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR).

In vitro

, WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-125601
Réf. fabricant18797056
Nom chimique ou matériau5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4 ]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1 H-tetrazole-1-ethanamine hydrochloride
CAS2247544-02-9
Quantité50 mg
CibleUbiquitin Ligase (E3) Inhibitors
Formule moléculaireC<sub>18</sub>H<sub>20</sub>ClN<sub>9</sub>S<sub>2</sub>.HCl
Pureté0.98
Une question, une configuration particulière ?
Contactez-nous pour un devis.