Potent and selective CCR4 antagonist
AZD 2098 is a potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis
in vitro
. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125612 |
| Réf. fabricant | 18799856 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>11</sub>H<sub>9</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>3</sub>S |
| Poids de la formule | 334.18 |
| Type de produit | Antagonist |
| Pureté | 98% |
