Potent PARP inhibitor
Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125615 |
| Réf. fabricant | 18799536 |
| Nom chimique ou matériau | 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone |
| CAS | 763113-22-0 |
| Quantité | 50 mg |
| Cible | Poly(ADP-ribose) Polymerase Inhibitors |
| Formule moléculaire | C<sub>24</sub>H<sub>23</sub>FN<sub>4</sub>O<sub>3</sub> |
| Pureté | 0.98 |
